You're going to have to get her when she is curled up, sleeping, probably. Hold her front legs together and put her in your lap. If you have two people, it will probably be easier for one to hold and the other to put the medicine in the ears. Make sure you massage the ears so that the medicine gets thoroughly applied. Then, get back, because they will shake their heads and sling that medicine everywhere! Ear mite medication seems tough to apply, but to me it is no where as bad as trying to give a cat liquid antibiotics or a pill! I'm alone, so I have to do it by myself. Mimi's claws are lethal, so I have to be so careful! Good luck!