Penny Lane has major anxiety problems. She will go absolutely ballistic if she is confined to a crate or a room and can't see either myself or Leo. Baby gates work fine as see can tell there are other people or Leo in the house.

I tried the DAP (Pheromones) and saw absolutely no difference in her anxiety level at all. My understanding is that it only works on dogs that were raised with their mothers and does not really work on dogs that were either hand raised or taken from their mothers at too early of an age.

I used rescue remedy at first as well as the DAP but never saw much of a difference from that either. I would put it in her water every time I filled it.

I now have Penny Lane on Prozac - and that has made a major difference. I understand your friends reluctance to use drugs, but the Prozac does not make her zoomy or sleepy at all - it just kind of takes the edge off her anxiety.