my female rottie has some stress/anxiety issues and we have tried every herbal/homeopathic remedy we can find. we didn't really see a behavior change with the rescue remedy. every dog is different tho so what works for us may not work for your friend's dog. i would encourage your friend to explore several herbal options -- be sure to give each ample time to work. here are some of the ones we have tried . . . .

rescue remedy - drops administered in water or on tongue

dap (dog appeasing pheromone) - like a glade plug in with a pheromone that mommy dogs give off (naturally calming)

comfort calm - tablets

mellow dog - treats

kava bones - treats

homeopet anxiety remedy - drops

those are just a few. the dap seemed to help and the homeopet anxiety drops also seem to help my dog. the trick with most of the treats/drops is that you have to administer them an hour or so before the stessing event. the dap is a continuous release. you can find any of these on the internet. i would suggest you do your own research on these remedies -- just so you know how they work -- some anxiety remedies out there are nothing more than sedatives. hard to re-shape behavior if your dog is too tired to concentrate. be sure to keep us posted -- hey you may find one that works better for us