Interesting the different reactions people have to the different anti-depression drugs. I had a bad reaction to Zoloft, but not Effexor (just stopped working) and Paxil....well.....when the nurse told me if I didn't take it everyday at the right time that it can be really nasty, I stopped taking it because I am really bad about taking meds and didn't want to end up in the ER with delusions. Basically I'm lazy about taking meds. And actually since I have stopped taking them I feel TONS better. I don't understand it, but I do.