I highly recommend the Honda CR-V, and I know there are a few other CR-V owners on the boards also.
I had a civic, and I loved it, but after our second addition, we needed more room!!
The CR-V is fabulous!!! We haven't taken a trip with all 4 yet, but 3 was a breeze last time we tried it. This vehicle has more room in it than it looks like. I found a Cherokee a few months ago that I loved, looked in the back, and said NO WAY!! Not enough room for the dogs. The seats fold down too, so I'm sure there is plenty of room for all 4, but even with the seats up, Abbey, Kito, and Riley were comfortable, and all three could lay down.

It gets great gas mileage also, and is reasonably priced.
Definitely look into one.