The longest that I'd leave my cats alone is overnight. During my last vacation, I had a co-worker coming over every day to feed them, clean their litter boxes, play with them etc. On work days, she was coming over during her lunch break.

One day only Sky came to greet her and she thought that this was strange. Well some how Storm, Sunny, and Cirrus had gotten locked into my spare bedroom. The door must not have been shut the whole way and one of them must have pushed it open. Thank god they were found by my pet sitter.

I don't know how long they were in there but it was long enough for them to try to dig there way out. They had clawed at the carpet under the door to try to get out or maybe Sky was trying to dig his way in.

I have a roommate now so if I go away, this kind of thing wouldn't happen again. I also consider my cats to be my children and I want them to have the best care when I'm gone. Luckily I'm not gone very much.