Originally posted by Karen:
<STRONG>My parents waited on their big female dogs (one Great Dane Mix included) until each had gone through her first heat, then had her spayed. Of course, during that heat, we kept VERY close watch - she was never outside without supervision, as we weren't taking any chances with wandering un-neutered strangers! Almost 4 months seems awfully early, I might call a second vet just to get a second opinion. Why remove her dew claws, by the way? Any particular reason?

And do, if you have one, post a picture - we'd love to see your big baby! </STRONG>
I don't know if you would want to wait that long beause when they go through there first heat they are more likely to get cancer. most likely Breast cancer. I think a good time would be around 4-6 months because they heal faster.