Wow today is sort of a morbid day for me. I just posted regarding someone's question of heart disease in dogs (my Whitney died of a heart attack). Now here liver disease is the topic in this forum. My Ashley, a 14 year old miniature poodle, died of liver disease on June 4, 1998. With her it came on very suddenly. One morning she just would not eat. I didn't think too much about it although it had never happened before. I figured everyone was entitled to not be hungry now and then. As the next few days went on would skip a meal or two and then when she did eat, it would come up. She appeared so hungry, poor baby, but could not keep it down. The vet examined her and took x-rays and said that her liver was 1/3 larger than it should have been and diagnosed liver disease. For starters he kept her in the "doggie hospital" on intravenous fluids for a few days to see if he could get her eating again. He was planning to do a biopsy but used the IV fluids first. When food was re-introduced she still could not keep it down. The bottom line is that we did not want to put her through any more and at 14 it was time to say goodbye. We never had the biopsy so don't know exactly for sure the nature of what caused the enlarged liver. For us it was the right decision because of her age and the suffering we had observed. I was with her until the end and even now it breaks my heart writing about it.