Where did your friend get this dog? Why did she get this dog? Was it only to use him as a stud? Did she have any idea what living with a large stud can be like? If she has no bond with this dog, will not neuter him and has little interest in caring for his health and emotional well being she has no right to have a dog. It is vital that she contacts the breeders and explains the situation to them, although it is unlikely they will stop breeding from affected dogs as they have not bothered to check what sort of commitment and care their pup would get once it left them.
I too am sorry if I sound mean and cross but this sort of thing makes me mean and cross!