We were recently on vacation for over a week and we had a neighbor come in an feed them, clean out the litter box, and even stick around a few times so that they wouldn't be lonely.

I think we have it worse than the kitties. They are pretty reslient, as long as someone is checking in on them daily.

If you do leave your kitty at home with someone to take care of it, write down specific instructions on how often they should visit, a list of emergency phone numbers in case the kitty gets sick (very unlikely, but it could happen), and the name of a vet. You can even ask a second friend or neighbor to check in a few times when you are gone. (it doesn't happen often, but sometimes someone we thought we could trust will flake out on us so having a backup person isn't a bad idea)

In the meantime, make sure that you visit the vet so that your kitty is current on shots and you'll have the piece of mind that your kitty is in good health.

Making these plans ahead of time will reduce your stress so that you can enjoy your vacation.