Noah, Noel, Basie and Livvy did this when we had Oliver....drove me nuts!! I was sleeping in the living room so David could be in the room with Oliver at night and it seemed that the cats felt better playing with him gone.

I really like this idea:
3. I give them some canned food before I go to bed at night so they have a full belly and they sleep longer. It's also good to feed them after a play session because it helps with the hunt then eat instinct that a cat has.

If that doesn't work, what about throwing toys AWAY from your bedroom when they come in at 4:30?? Like, have a stash of mousies in a drawer or something.

Good luck! I hope you sleep really well.