Oh geeez. I wish someone with more experience in this area would post. I have never had a dog who had a litter, so I personally can't offer any help. I'm sure though, that if the mother refuses to nurse them, they must be hand/bottle fed round the clock. My advice would certainly be for your friend to call her vet ASAP!!! It is critical that the puppies get the warmth, fluid and nourishment they require. They are so vulnerable at this stage and every hour without sustanence puts them in peril. Please tell your friend to call IMMEDIATELY and let us know what advice they gave! Poor puppies! Please be strong little guys and girls.