I forgot to add in my post that if an antibiotic is being used and lactobacillus/acidophilus (good bacteria) is also to be used, it should be given at Least 2 hours before or after the antibiotic. Some articles on lactobacillus/acidophilus mentions this and some do not. I learned the hard way as I was giving it the same time as the antibiotic and was knocking down the effectiveness of the antibiotic. It took 3 rounds of an antibiotic I was giving my dog before I realized what I was doing (knocking out the effectiveness of the antibiotic. When I gave the lac/acid. 2-3 hours after the antibiotic, my dog got over his infection.