Her discomfort could either come from fleas dying (they are more active then), and/or the product itself.
In addition to the topical flea treatment, you could also give her a 24-hr flea pill (Capstar, generic: nitenpyram, not a prescription but OTC). Frontline and Capstar can be given together.
Sometimes, generic brands don't work as well as the brand name product.
But as Karen said, do not apply more of the Frontline, and clean, clean, clean.
Treat any other pets living in the house as well. Also watch for tapeworms as fleas carry their eggs.






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