Sandie - there is so much that she can't take, and Adequan is one of them. Most of what would be able to help her she can't take because of her kidney issues, and also because of the previous GI bleed. She takes 1/4 of a 50mg Tramadol tablet twice each day, and she's really at the max on that since she only weighs a little over 9 lbs. She also takes gluco/chrond combo tablet, but I really don't know how much help that is at this stage of the game.