Definitely take him to the vet. It could be a lot of different things, some of them more serious than others. It's not worth an emergency vet trip tonight, but I'd call the vet's office when it opens, and ask if they can see him that day! It's not uncommon for a kitten to have a heart murmur and lots outgrow it, but the coughing and lack of appetite are cause for concern.
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