Well, Tex is the only one I pill regularly (2x day), and he is like a gift from above, thankfully.

But, for some of my more rascally ones, this works, for me. First, put on jeans. I get the meds- be they pills, liquid, whatever, and have it all ready to go, ALONG with a treat. I then get on my knees, and put the cat between my legs, my feet serve as a fence to the rear. I am then physically over the cat, and they can scooch as much as they want, but, they aren't getting anywhere (have YOU seen my thighs?), and open the hatch! Then, I immediately treat them with the yummy treat. This, for me, works better because, 1) I live alone; 2) too much hooman is scary- they know something is up with more people;3) I stay calm which helps them stay calm; 4) they are on the floor, not the counter, table, etc.

Just an idea! Good luck.