Absolutely take the time to write down some things. There is nothing more frustrating to an interviewer than candidates who give short, vague answers! (Had two of those yesterday...)

Make a list of what you think the interviewer will want to know about you - or SHOULD want to know about you. Both technical and behavioral. By behavioral I mean - dependable, able to work with little supervision, gets along well with others, etc. Then think of a story from your professional/educational experience that demonstrates your skills/abilities in each area. Specific. When I was working on the ABC project I discovered that XWQ happened and I fixed it by MKI. Make notes to have in front of you.

If they ask the question..."tell me about yourself" be prepared to talk about how you became interested in your field, your successes, the challenges and how you overcame them. They are not, or should not, be interested in whether you are married, or have children, or personal stuff.

Even if they ask a vague question - go with a very specific answer.

You also need to prepare your questions. Have a couple questions about the organization, the position for which you are interviewing and...the interviewer! Such as "how did you get involved in this project" whatever. Asking people about themselves is very flattering and builds a bond.

And do not forget your thank you notes. Email is fine but send within 24 hours.

Good luck!