Kitties can be crazy. One of their charms is that life is on their own terms. Could be any number of things. Is she a tortie per chance. My sister and BIL have a kitty that HATES my sister and adores my BIL. It is so obvious the glares she gives my sister. Especially if she is cuddling with her husband. Who knows why? You might consider a kitty whisperer to ask Hoobley what's on her mind?
Claudia