The "O" should help!

Here’s the puzzle!

A **S* O* THE *O*S. *N*ORT*NATE**, WE SO*THERNERS *I* THIN* WE WERE *O*S.

MAR*ARET MIT*HE**
*ONE WITH THE WIN*

Letters to guess:
CDFGJKLPQUVXYZ

GOOD LUCK!

KAREN: 9 T'S, 6 N's - 15 POINTS TOTAL
RANDI: 12 E'S - 24 POINTS
HAPPYLABS: 4 A'S, 6 R'S, 5 I's, 6 O's -36 POINTS TOTAL
FRECKLES: 5 W's, 2 m'S 7 POINTS TOTAL
FELICIA'S MOM: 6 H's, 6 POINTS
KILLEARN: 5 S's, 5 POINTS