I gave my cat Puddy subQ's twice a day, then backed off to once a day, then a couple of times a week. As she grew older and sicker (she had other issues besides CRF) I gave them once a day again. The needles are quite thick but that's so that the treatments will go quickly. It's usually over in approximately 5 minutes. I injected B vitamins (or just B12 if you prefer) directly into the port on the bag which really helped to give Puddy more energy and kept her mentally alert b/c she was also suffering from dementia, poor girl, which can be a problem w/CRF cats, especially when they're much older. I bought my supplies directly from my local vet. For one bag of fluids, a box of 12 needles and a line, I paid $12.50.

Good luck. My Puddy's life was extended by several years due to subQ's.