I have a pet sitting business and am often away from my cats for a couple days at a time. Laura's Babies is right. When you get back, you'll get ignored by some, velcroed by others. They get over it the minutes the can opener comes out.

Cats, as long as they have adequate food, water and a litterbox, can be left alone for a night or two. Make sure you put a nighlight on and a radio. They'll be fine!