Nope, haven't tried Zoloft. They were on Buspar and Elavil to no avail. I'm glad you're keeping an eye on the bladder thing. Good luck w/the Zoloft and keep us posted. If you're going to medicate her only for a few days, Ametryptilene is probably the way to go. You can't miss a dose w/Clomicalm or it stops working so unless your cat sitter can dose her, it might be best to leave it alone. Good luck w/whatever you decide.