I'm so sorry to read that Scruff is not well. Here's hoping that things will turn around for him in no time.

All of this sounds very familiar to me, since I went thru a lot of the same with my Pom Myndi this past June and July - loss of appetite, lethargy, staggering and weight loss. Did your vet check for blood in the stool sample? With Myndi, it was a GI bleed from somewhere. Her RBC was at a very critical 13 and that was causing the staggering and lethargy, since not enough oxygen was getting to her brain, and she actually passed out once and I thought at that point that I had lost her. She also lost 2lbs in a very short time, and being just a little Pom, then that's a huge amount. Her vet didn't want her on Pred because of her age (almost 15), but she was on high potency vitamins, Flagly and Sucralfate. She was extremely sick and the prognosis did not look good. However, her appetite picked back up and she was eating like a horse, and in 2 weeks when she went back to the vet for a checkup, she had put 2 pounds back on and her RBC was up to 37. Energy level was back, no more staggering or wobbling, and appetite continued to be great. Then when we thought all was well, the severe diarrhea started, so back to the vet and a diagnosis of probable IBS. She got a shot of Reglan and put back on Sucralfate and another antibiotic, and is now back to her bouncy, spazzy self.

Perhaps you could run this by your vet and check with him about a GI bleed. I know you said there was a growth on the spleen, but maybe there is something else going on too. Just a thought.............

Prayers going out to you and Scruff, that he will be with you for a long time to come. PT prayers work miracles - they did for Myndi!