PT prayers requested please.

[K9soul]

Julie,

I'd stop the meds again and think about getting a second opinion. That's a pretty high dose of thyroid med. Tommy has been on 0.8 mg twice a day and he was recently pushed back to 0.5 mg twice a day because he was a tad hyperthyroid on his last blood test, and he is a big boy. He has autoimmune thyroid disease and has a totally nonfunctioning thyroid. Too high a dose of thyroid med can cause hyperthyroidism, and hyperthyroidism CAN cause seizures, confusion, spells, or other symptoms.

You and Molly will be in my thoughts.

[GoldenRetrLuver]

Thanks again everyone. I heard back from the vet yesterday; all of her tests came back and all of her levels were within normal range. Which is good news!

And no episodes/fits today either! Jess, that's exactly what I was thinking. My vet was and still doesn't think the thyroid meds have anything to do with her symptoms, but I disagree. I have not given them to her since the evening we brought her home and she seems to be doing loads better now. He was very surprised when I told him that she had started up again the same evening I brought her home after not having any problems when she spent the night at the vet whatsoever (she was not given a pill the entire day while she was at the vet, and was given one when I brought her home). I'm still documenting everything at the request of my vet and for my own personal knowledge so we can either rule-out the thyroid meds or see that that's where the problem lies. I'm thinking the meds should be completely, if not almost completely out of her system by now which would explain her improvement. My vet is calling again tomorrow night to discuss how she's doing and what our options are if she goes back to acting like she was.

I'm hesistant to put her on seizure meds if she does in fact need them. The first medication isn't an option for her because mixing it with her thyroid pills would be dangerous. The second medication would weaken her hind legs and she's having enough trouble getting up and walking around now as it is. First and foremost, I'm going to have them put her on a much lower dose of the thyro-tabs and see if that makes a difference. My gut feeling is telling me that's what the problem is.

Thanks again guys, I'll continue to keep you updated on her progress. So glad she seems to be taking a turn for the better!!

[Catlady711]

Glad to hear the fits have stopped now, that must have been scary for both of you!!

You wouldn't by chance know what your dog's T3/T4 levels were when she was diagnosed do you?

At work dogs are typically dosed on a twice a day schedule and the size of the dose is based on the T3/T4 levels and the dog's size. Then we retest the levels once the dog has been on the medication 4 weeks and adjust the dose accordingly.

I looked up the label for Thyro-Tabs. Since it's a human product it's hard for me to tell how much of the warnings apply to dogs, however I did find a couple things that might apply. Now bear in mind that they are required to put ANY reaction or side effect on the label even if it's one person out of 10 million that had a problem with it so don't get too frightened over some of it.

thyro-tabs Due to the long half-life of levothyroxine, the peak therapeutic effect at a given dose of levothyroxine sodium may not be attained for 4-6 weeks.

The signs and symptoms of overdosage are those of hyperthyroidism (see PRECAUTIONS and ADVERSE REACTIONS). In addition, confusion and disorientation may occur. Cerebral embolism, shock, coma, and death have been reported. Seizures have occurred in a child ingesting 18 mg of levothyroxine. Symptoms may not necessarily be evident or may not appear until several days after ingestion of levothyroxine sodium.

Treatment of Overdosage

Levothyroxine sodium should be reduced in dose or temporarily discontinued if signs or symptoms of overdosage occur.

Acute Massive Overdosage This may be a life-threatening emergency, therefore, symptomatic and supportive therapy should be instituted immediately. If not contraindicated (e.g., by seizures, coma, or loss of the gag reflex), the stomach should be emptied by emesis or gastric lavage to decrease gastrointestinal absorption. Activated charcoal or cholestyramine may also be used to decrease absorption.


If it were my dog; I'd have her stay at the vet another night and let them give her the medication there. If there's a reaction they will be there to witness it which may tell them something. Or possibly have the T3/T4 levels retested. If your vet doesn't want to do either then I'd be looking for a second opinion.

[K9soul]

I'm so glad to hear she's doing better today. It would definitely be hard not to suspect the medication, either a side effect or that it is possibly raising her thyroid levels too high and causing hyperthyroidism. Having had collies, in my experience they can be ultra sensitive to medications and prone to reactions. I remember having to be careful what heartworm preventative I put them on because of that. I think you're right to go with your instincts and your plan sounds like a good one. I'll be keeping you and Molly in my thoughts. ((hugs)) to you.