I'd have to say Great Dane because now that we've got one, I never want our house to be without one! I love this dog, she makes me feel very good about the breed, especially since everything she does I hear other dane owners say there's does too. St. Bernards are beautiful dogs and the one I met had a great temperment and was a great dog. However, I'd have to do a lot more research before I decided to get one of those. Of what I do know, they drool more than most other dogs, including the dane, and they're fur is so long and full that they shed a lot and even if they are brushed often. So, I'd definately without hesitation have to reply that I'd go with the dane!