Hi Trevor, I'm new here to, but Welcome to you.

I have to agree with all the previous posts. Always start with a vet check whenever your pets seem "off"--if behavior changes, litterbox/toilet habits change, eating patterns change...the vet is always the first person to consult.
Cats can hide illness and injury well and only a vet knows how to check for these things properly.

And, your wife does need to understand that cats can be quite independent creatures and they don't like things forced on them. She needs to give Mr. Skibby his space and allow him to settle in on his own terms and accept her on his own terms.