My sister moved with her 2 cats and a dog from Florida to Washington state in one of those big moving trucks (the U-haul or Penski) and her cats did fine during that 5 day trip. If you are going in a car, you will need a litter box, food and water for them... If you are going to use a big truck I would keep them in the cab of the truck but have a big cage in the back for them with a litter box, food and water to put them in from time to time so they can stretch their legs and move around.

When my brother moved from New Orleans (west bank) to Oregon, they didn't take their cats because theirs had health issues and were already traumatized by Hurricane Katrina and they knew that long car trip would traumatize them and make their health issues worse. They rehomed them with a friend.

If you have to fly them, a lot of vets will not sedate them and some airlines have a problem with them being sedated as it is to dangerous. I have flown cats and they did just fine (unmediated)..

I suggest if you have to travel by land, to start taking them out for short trips in the car locally and if you have time increase the time from short times to longer times. It will show them that although they may not like it, it WILL end and they will be OK.. I've had several cats that loved traveling in a car and use to take them on vacations with me.

The ones I have now do not like traveling, even short trips. I have found if I put on soft classical music they calm waaaay down. In a car DO AVOID loud music with them, none of that BOOM BOOM stuff as it has been proven that loud fast music excites them. The slower the music, the more calming it is. Also you can get some calming spray to spray in the car to help them out some.