What dosage of DES was she on? My girl, Pirate, had to take it every three days for it have any effect. My vet said that was the absolute maximum dose he would prescribe. If she still needed help after that, he would have added a second drug, PPA I believe. Fortunately every three days worked for Pirate, but I could tell within 12 hours if I forgot a dose! My Sleet has taken DES once a week for about 18 months and that low dose works for her.

I hope you find something that will help. Diapers can't be much fun for either of you!