When I moved with Scooter Bug from Texas to Arizona, we broke it into 2 days. Scooter had water in his carrier, and a small pan with litter just in case, also in the carrier... I was a bad mommie and he rode on my lap most of the way though. He had free roam, it made him more comfy.

At the hotel the night we stayed, I had one of the disposable litter trays for him in the room with us. I put out food and water and let him have free roam. He was MUCH happier than being cooped up in the bathroom all night.

I did have him updated on all of his vaccinations before we left Houston.