My RB Puddy was on Epogen but Dr. Lee told me that it would take several weeks, possibly months, before it began to work and she had so many other problems and went to the Bridge before I could give a definite opinion one way or the other. I will say, though, that injecting the B vitamins into her subQ fluid bag was the best thing ever to bring improvement. Her dementia left immediately and she got her appetite back, too. She only lived for two days afterwards, though, so I wish I could tell you that Epogen was worth it but she just didn't have enough time on it. Good luck w/Norton and please know that you both are in my prayers. I hope that the Epogen works for your sweet boy.