I've dealt with the hyperthroid, and given the medicine for that. I gave it by pill though.

I will say that the cat that was on the medicine, once he was out of the shelter (he was a shelter cat), was here in my home and was given good foood and got his thyroid under control, the dosage of the medicine went DOWN. It was 2xs a day, to 1x a day to a very small portion of the pill 1x a day.

Hopefully your guys will feel better, and get the thyroid under control and then they won't need to get 2 doses a day.

I'm not sure how the rub on cream works... I used the pills. Mac was very easy to pill, and I think I took this for granted, because I now have some cats that are impossible to pill! Figures!