Wow, that's a lot of information, and really interesting! In fact, I'm thinking about showing this to my vet. Thanks a lot for looking for all these information!

I had no idea that an idiopathic/interstitial cystitis affects the nervous and endocrine system as well! Will ask my vet re. a possible failure of her adrenal glands. It's funny that I recently had such an ACTH test done myself (still waiting for the results), as - along with my thyroid condition - my hypothalamic-pituitary-adrenal axis is messed up big time. Would be almost eerie if Luna was dealing with the same thing! Most of the symptoms posted for adrenal exhaustion are very familiar to me!

Re. the s/d: It's not her regular diet, she's usually on a crystal prevention diet, but sometimes the crystals reoccur, so I need to change her diet back to s/d. Right now, there is such a time. She's on s/d for maybe two months now, and will be for one more month.

Re. the twitching: It really seems to be worse when she's in my arm. Funny thing is that whenever I put my hand on her back, she'll calm down and the twitching stops.

Kirsten