Thanks for all the great suggestions everyone. You have a lot of good ideas and I am very impressed with those of you who can pill a cat by yourself without having someone else help.

I did try to trim Izzy's nails when she was all cozy on my lap a while ago. I clipped one back claw and she tried to nip me. So that is one claw done for today and that may be all she lets me do. I wanted to trim her back claws because last night when we tried to pill her, when she jumped out of my husband's grasp she launched off with her back feet and nailed him in the stomach as well as scratched his neck a bit with the front claws. She is a real twisty contortionist when she wants to get away and she is fast.

We will try again tonight to pill her, luckily it is only the one dose the vet said they needed. Milly got hers done so we don't need to torture her tonight, just Izzy.
Emily the Spoiled, that is interesting about the Drontal needing more than one dose because when I looked up the treatment for worms online it said 2-3 treatments but when I picked up the pills at the vets office I double checked that it was one pill one time and that is what she said.

If we can't get Izzy to take the pill tonight, I will look into getting pill pockets or a pill shooter. I see that they are both available at Petco which isn't too far from me. Will they usually be available at a vet's office? It is much more convenient to stop by the vet's office in town instead of driving a long way to get them.

Moosmom, this time I will have to try blowing on Izzy's nose, I knew to rub the throat and hold the mouth shut but I didn't read about that until after I tried to pill her.

Sas, I know you were able to trim a few claws on one of my cat's when you came to meet them in September. I can't remember which one let you do it, but I do remember to try and do it when they are sleepy and relaxed.
Thanks for all the help, I will let you know how it goes later.