The Pill Pockets are wonderful inventions (I have one cat who gets a pill every day). If that doesn't work, I have put the cat in a sweatshirt sleeve with their head out the cuff (the rest of the body is then trapped). That allows me to open their mouth and shoot the pill in.

To clip their claws I hold them between my legs and basically "sit" on them to hold them in place. Clip their front claws and then have some treats ready...(I don't normally clip the back unless necessary)