We had problems like this with Tuna. If you didn't feed him the second you got out of bed she would spray. We couldn't leave out food for him because he was so obese, the vet kept telling us to put him on a diet which made him only spray more. He ate more than enough however in his mind he wasn't getting nearly enough food and would let you know by running to the door and spraying. We had tried everything when finally I told Alexa that I had enough. I was tired of walking into a house that smelled like pee. We couldn't buy any new furniture because he peed on everything we owned, I didn't even feel like I could have guests in my home because of him. Finally after telling her that something needed to change we took him to the vet for prozac. He hasn't had an incidents since we put him on the prozac. I know that some people are against medicating for that, but I think it was the best thing for us. We were finally able to have our house back.