I had a total hysterectomy in 2001. I went into immediate menopause and for the first six months tried several different types of hormones to control the hot flashes and severe mood swings. My hot flashes were so bad that sweat would run down my body. I'm not ashamed to say that Premarin is the only thing that has helped me. Once we got the dosage regulated, my life has evened out and is so much better.