Yes, I'm wondering too if the weight around the middle is just inevitable. My gyn told me that I had every symptom of ovarian cancer so I had a pelvic ultrasound and a CA125 blood test but they both came back normal. My family dr. feels I'd benefit from HRT but I fear that the risks outweigh the benefits, according to what I've read, which admittedly isn't much. I would never judge someone for taking Premarin or for not taking it. It's a personal choice.