Red flags would be going up for me as well, but I wouldn't waste my energy confronting her. She might just be one of those people who know how to get your goat. Then when you respond, she complains to new hubby about his niece who was *so rude to her*.

What she says about Keegan, it a non-issue. It holds no weight with anybody now that we have a inkling of the type of person she is. What you do care about is your relationship with your uncle and out of love and respect for him, I would think it best to be polite and cordial, but that is all. If you want to address the issue once out of concern (albeit feigned), fine, but do it with care as you would with a friend.