Senility may have something to do with it, but it could just be a fear of being alone. We old folks tend to dislike that more than when we were young

Doggy senility is a reality. I had to send Samson to the bridge a year sgo because of it. He was destructive day and night and forgot who I was at times. In a crate, he bounced the crate around the room! He would growl at the other dogs and cats. I couldn't trust him even though I knew he had no idea what he was doing. He was somewhere in the 15 to 17 year range. (Former stray)

The only thing you can do for Emme is to crate her when she might be destructive. Don't put anything in the crate with her. It sounds cruel, but it's for her safety too. Also the crate could be in the bedroom so she wouldn't feel so alone in the bathroom overnight. Maybe a large crate so she wouldn't need to sit in her own urine. (Elevate one end slightly to direct the urine).

If she can't see well, she will dislike being alone more.

Unfortunately this isn't going to get better. The vet might have a medication that can slow the advance.

She sounds like a very loved dog. I commend you and her parents for thinking of her comfort during these stressful times.