I see Luminol is Phenabarbital. Snoopy took Phenabarbitol for 4 of his 6 years of life. It did end up damaging his liver but it also gave him and us time I don't think we would have had without. Snoopy had other health problems too so it wasn't just the liver damage that caused us to have to choose to put him down.

That being said, I am surprised your vet has not increased the dosage of luminol you give Jackie or added something else like potassium bromide. Snoopy did well on the meds - usually going 4-6 months without a seizure but then he would have a couple in a couple of weeks time and not have any again for awhile. Continuing to have seizres like Jackie is doing can cause kindling which is where the brain begins to think that is the natural way to react to whatever is bringing the seizures on. And they will become more frequent.

My vet said that you can run all kind of expensive tests to see if you can find the trigger to the seizures. But most of the time they don't find anything. Having a dog with seizures especially with the cluster seizures which it seems Jackie is having is very difficult to handle emotionally for us humans. Snoopy had grand mal which means he lost control of his body's functions which meant there was a mess to clean up each time he came out of it. Trying to clean up after and then deal with a confused lost, somewhat temporary blind dog can be very tough. A couple of times he got his jaw clamped on the side of his kennel and once on the fence outside - that was very disturbing because there was no way to "unclamp" it and you had to try to hold him still enough to not do damage.

I will keep you and Jackie in my thoughts and prayers.