We had to get creative with Giz and her heart medicine. She would eat the pill in the pill pocket for awhile, then would have nothing to do with it. Then we would crush it up and crush a treat up with it and she would eat that. Now, with Amy and Boo on the Cosequin I buy canned cat food and mix all the meds in that and they get that as a treat. A half a teaspoon is all they get with their meds each night and that is now their new treat.