I used to have that problem with 3 cats going after Dusty. I just figured it was because she was older and had health issues and the other cats sensed it. The last couple weeks I did have to confine Dusty to a room of her own so she could have some peace.

I'm not sure my theory holds up with the weakness thing because now I've got 3 cats (two of which went after Dusty) going after Cami (who was also one that went after Dusty- paybacks?). I think in my house it's just the cats don't like the oldest females. I dunno.

I do sympathize with your situation though. If Puddy likes the room, has her stuff in there and needs the peace then I'd go ahead and shut her in when you're not home if it was me.

Good luck.