Ya gotta do what works for you. My house is small, just under 1800 sq. ft. All my litter boxes are in the basement. I like them as far away from the kitchen and dining room as possible. I do have one in the second guest room for Puddy because she's in CRF and I let her sleep separate from the other cats because sometimes Coco Puff gets too rambunctious for her and gets her upset, then she goes downhill fast. I clean all boxes twice a day, sometimes 3 if I feel there's been heavy traffic. Since I'm no longer actively involved in rescue, I don't foster any more either. I made up my mind that my new house was for me and that means the cats have got to mind their manners. So far, so good.