The primary long term effect of prednisone is kidney failure. If humans are on it long term, they have to have blood work twice per year to test kideny function. And to this day I believe that is what did in my Mr. Amber Cat. He was given prednisone for pain relief for fused vertebrae in his back. After 3 years on once per day 5 mg, he developed kidney failure and was gone in 6 months.

Bobby was on prednisone for his itching and rash, but I refused to keep him on it. Changed vets, and the n ew vet agreed not to keep a 1 year old on it long term as it will shorten his life. Right now Bobby is taking over the counter Chlor Tri Meton, and wearing an e collar.

Can you keep on the depo shots indefinitely? If so, could you just put an e collar on for the last week or so when it wears off but she can't have the next shot yet? Bobby can't have depo shots, so I don't know a thing about those.