The way you see vet & vet techs hold is probably the best. You will need 2 people one to hold & one to apply the drops. (kind of hard to explain in writing but you can have your vet show you) You sit or stand facing the dog with the arm closest to the dog you wrap around the neck (start from the top of the neck and your hand should rest under the throat) then with the other hand you grab the muzzle. Not too much pressure. Also if you can lift your dog up onto a table or something sometimes it helps as this is not the dogs ground or territory. Keeping the dog preoccupied is helpful too, peanut butter works good as the dog does not have to chew much, also the spray cheese in a can works great just keep spraying while the dog licks it! Also a couple times a day I would just hold the dog as this way he will think that something bad is not going to happen every time he gets restrained. If you continue to do this even when no meds are needed it will greatly help for the next time. Also do not talk in a baby squeeky voice when he is not cooperating as this only praises the dog for acting like that. Be firm so he knows you are the leader and PRAISE when he behaves!!!!