I'll second the idea of desensitization. A possible sequence would be:
Step 1. Place puppy in car with you in the back seat -engine off. Try this for just a few minutes a few times per day. Give puppy a treat.
Step 2: If puppy is mellow, then do the same with the engine on. Most likely it's the noise of the engine that is freaking puppy out. Try putting the radio on to help drown out the engine a little.
Step 3: With you in the back seat with puppy, have someone back down your drive way. Then pull back in.
Step 4: Puppy goes around the block. Still with you in the back seat.
Step 5: You get to drive around the block, with puppy in back.
Step 6: Increasing duration of distance and time in trips.
You may or may not still have to drug puppy with benedryl or the like for long trips. Don't forget the treats when training! Puppy will soon associate car ride with free treats.
With mine I made it a point to introduce them to frequent car rides as soon as I got them. Now all I have to say to them is: Do you want to go for a car ride? or Do you want to go to the store? And zoom they go running to the car door waiting to be let in. When I return to the car each gets 1/2 of a small puppy treat. The more stops the better puppies like their car ride.
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