I'm not familiar with that substance. And I'm not as familiar with Advantage, however Frontline Plus has an extra ingredient that when the animal sheds hair/dandruf it takes that ingredient into your carpets/furniture to help stop the larva stage of fleas, as well as the main ingredient in Frontline Plus also kills adult fleas on the pet. The ingredient Fipronil in Frontline Plus is the same ingredient used in fruit orchards in the US since the 1980's it's very safe. Frontline Plus is pricey, but actually less expensive than using a myrad of other more chemical methods that only partially solve the problem or just plain don't work.

Either way, if fleas are biting people it's a BAD flea problem and could take up to a year or more of regularly treating the pets to get it back under control. Vacuuming alot (throwing away the sweeper bag), washing pet bedding will all help also, but that alone will never stop it. A single female flea lays 2,000 egss in her short lifetime, and fleas can live for months as larva stages in your carpets.