I pet and coo to the cat, straddling from behind (do not sit on the cat, place kitty between your knees), hold her in place with your hand on her chest. Stroke and pet, get her purring. Gently nudge her chin upward. Grasp her chin, gently open mouth with your fingers. Insert loaded syringe, squirt very quickly and then close kitty's mouth with your fingers. Hold the mouth closed while you plant a kiss on her sweet mouth, stroking her throat. It works every time with the M's. Reward with a treat or two or three, before kitty runs to hide under the bed