Yes. Before we got Sprinkles fixed she had lots of litters The babies that we have of hers (that aren't really babies anymore) are Sky, Heavon, Uno, and Jaws.
Heavon had one litter but ate her babies
Daphney has had 2 litters-Nitis and Sugars are her babies (and my RB Checkers )
We found out Triskit was pregnant when she got fixed. But she wasn't that far along and we just couldn't take care of any more puppies anyway.